Tetracaine hydrochloride

Iinkcukacha zemveliso

MF: C15H25ClN2O2
MW: 300.82
CAS: 136-47-0

1.ITetracaine hydrochloride sisithomalalisi sendawo esisebenza kakhulu esinokuvala ukusebenza kwemithambo-luvo ngokubuyisela umva.Isetyenziswe kwi-anesthesia yokungena, i-nerve block anesthesia, i-epidural anesthesia, njl. xa kuthelekiswa ne-procaine, umphumo wayo we-anesthesia wendawo ubalulekile, kwaye isetyenziswe ngokubanzi kwiklinikhi.Ngokufunda iindlela ezikhoyo zokudibanisa, kufunyenwe ukuba i-synthesis ye-p-butylamino benzoic acid ephakathi linyathelo eliphambili kwi-synthesis ye-tetracaine hydrochloride, eneziphene zezinto ezingazinzanga okanye isivuno esiphantsi.Izazinzulu ziye zayiphucula le nto.Kwi-1981, bacebise ukuba benze i-p-butylamino benzoic acid nge-alkylating p-aminobenzoic acid kunye ne-1-Bromobutane.Nangona kunjalo, ngenxa yokwakheka okungenakuphepheka kweemveliso ze-dibutylation kunye nobume obungazinzanga bezinto eziluhlaza, le ndlela ayifanelekanga kwimveliso yoshishino.

I-2.I-Tetracaine hydrochloride isetyenziselwa i-anesthesia yendawo ye-mucosal, i-anesthesia yokuqhuba, i-epidural anesthesia kunye ne-subarachnoid anesthesia;Isetyenziselwa i-anesthesia yendawo ye-ophthalmic, ayithinteli imithwalo yegazi, ayilonakalisi i-corneal epithelium, kwaye ayinyusi uxinzelelo lwe-intraocular.

3. Eli chiza linokuphucula i-nerve block effect ye-cisatracurium, kwaye i-dosage yokugqibela kufuneka incitshiswe xa idibene.Xa idityaniswe ne-adrenaline, inokunqanda imithambo yegazi, inciphise ukuhamba kwegazi, ukufunxwa kancinane kweziyobisi, nokwandisa ixesha lesenzo.Kodwa ukudibanisa kwezi zibini akufanelekanga kwizigulane ezinesifo senhliziyo, uxinzelelo lwegazi, i-hyperthyroidism, isifo se-vascular peripheral njalo njalo.I-Hyaluronidase inokwandisa ngokufanelekileyo ukusasazwa kwesi sidakamizwa, ukukhawuleza ukuqala kwe-anesthesia, ukunciphisa ukuvuvukala kwendawo, kunye nokuthintela ukubunjwa kwe-hematoma.Nangona kunjalo, i-hyaluronidase inokukhawulezisa ukufunxwa kweli chiza, okukhokelela ekwandeni kwe-anti chemical Book toxicity yeli chiza.Eli chiza liphuma kwi-p-aminobenzoic acid (PABA).I-sulfonamides yenza i-antibacterial effect ngokuthintela i-PABA yeebhaktheriya.Xa eli chiza lidibene ne-sulfonamides, umphumo we-antibacterial we-antibacterial uya kuvinjelwa, ngoko ke zombini akufanele zidibaniswe.Eli yeza li-acidic kwaye akufanele lixutywe kunye neyeza le-alkaline liquid;Nkqu neziyobisi ezine-acidic zinokuchaphazela ixabiso lokuqhawula ichiza ngenxa ye-pH eyahlukileyo, okukhokelela ekunciphiseni isenzo okanye ukulibaziseka kwexesha lokuqala.Ukulungiswa kwe-iodine kunokubangela imvula yeli chiza, ngoko indawo yokutofa yeli chiza ayinakusetyenziswa.

Isicelo

Le mveliso yi-ester esebenza ixesha elide yokubulala iintlungu.Iimpawu zayo zesenzo zi: ukungena okunamandla kwi-mucosa, ifanelekile kwi-anesthesia yendawo, kwaye akukho zithintelo ezimbi ezifana ne-vasoconstriction, i-mydriasis, ukulimala kwe-cornea emva kokuhla kwamehlo.Isetyenziswa ngokuqhelekileyo kwi-ophthalmology.Impembelelo ye-anesthetic yendawo kunye ne-toxicity malunga namaxesha angama-10 amakhulu kune-procaine.Emva kwesitofu, umphumo we-anesthetic we-chemicalbook ubonakala ngokucothayo (malunga nemizuzu eyi-10), kwaye imetabolism nayo icotha emva kokufunxa.Ixesha le-anesthesia yendawo ukuya kwi-3ij, h, -j.malunga.Isetyenziselwa ikakhulu ukuthomalalisa umphezulu weliso, impumlo kunye nomqala womqala, kwaye ayifane isetyenziswe ukwenza i-anesthesia kunye ne-epidural anesthesia.Ngokuqhelekileyo, ayisetyenziselwa i-anesthesia yokungena ngenxa yetyhefu ephezulu.