Iinkcukacha zeMveliso

CAS:443-48-1

I-1.Metronidazole iyi-antibiotic ye-nitroimidazole, eyaziwa ngokuba yi-methotrexate, i-metronidazole, i-metronidazole, i-metronidazole, i-methotrexate, i-anaerobic microorganisms inefuthe lokubulala, iyancitshiswa emzimbeni womntu xa i-metabolites eveliswayo nayo ine-anti-anaerobic bacterial effect, inhibit I-synthesis ye-deoxyribonucleic acid yebhaktheriya, ngaloo ndlela iphazamisa ukukhula kwebhaktheriya, ukuveliswa kwakhona, kwaye ekugqibeleni kubangele ukufa kwebhaktheriya, i-anti-anaerobic bacteria iPu iquka: Bacteroides fragilis, iClostridium (ngenxa ye-anti-anaerobic ibhaktiriya ibandakanya: Bacteroides fragilis, Clostridium perfringens ( Ithiywe ngenxa yeencam ezibukhali zebhaktiriya), i-Bacillus tetani, iStreptococcus pepticus, iStreptococcus pepticus, kunye neJaChemicalbook flagellate. ebangela usulelo emlonyeni, kwaye ngo-1978 ichongiwe yi-World Umbutho wezeMpilo njengechiza elinamandla ngokuchasene nosulelo lwe-anaerobic kwaye lisetyenziswa ngokubanzi kuthintelo kunye nonyango lwezifo zomlomo ze-anaerobic.Ikwasetyenziswa rhoqo kwizibhedlele zokuthintela kunye nokunyangwa kwezifo zokuphefumula, zesisu, isisu kunye ne-pelvic ezibangelwa yibhaktheriya ye-anaerobic, ulusu kunye nosulelo lwezicubu ezithambileyo, izifo zethambo kunye nokudibanisa, i-carditis, i-sepsis kunye nengqondo.

I-2.Indlela yokwenza isenzo kukuvinjelwa kwe-redox reaction ye-amoeba protozoa, ukwenzela ukuba i-nitrogen chain ye-protozoa iphulwe kunye nesiphumo.Uvavanyo lwe-in vitro lubonisa ukuba kwi-concentration ye-1 ~ 2mg / L, ukuguqulwa kwe-morphological ye-ameba ye-Chemicalbook tissue ingenzeka kwi-6 ~ 20 iiyure, kwaye zonke zingabulawa kwiiyure ze-24.

3.Ikristale emhlophe okanye etyheli okanye i-crystalline powder;ivumba elibi, ikrakra kwaye inetyuwa kancinane.Inyibilika kancinane kwi-ethanol, inyibilika kancinane emanzini okanye kwiklorofomu, kancinane kakhulu ukunyibilika kwi-ether.I-Methyl Chemicalbook nitrazole yi-nitrogen-containing heterocyclic compound kunye ne-alkalinity kunye nokunyibilika kwamanzi aphantsi.Ngokomgaqo we-premedication, i-metronidazole yenziwe kwityuwa ye-potassium phosphate, kwaye ukunyibilika kwamanzi kwanda, okunokusetyenziswa njengesisombululo sokutofa.

Isicelo

I-1.Isetyenziselwa unyango lwe-trichomoniasis ukususela kwi-1959 kunye ne-intestinal amebiasis yangaphakathi nangaphandle ukususela kwi-1970, kunye nokusebenza okuphezulu, ubuthi obuphantsi kunye nesicelo esibanzi.Ineziphumo ze-mutagenic kunye ne-teratogenic kwiimvavanyo zezilwanyana.
2.Isiphumo esinamandla se-antibacterial ngokuchasene neebhaktheriya ezininzi ze-anaerobic
3.Kunyango lwe-amoebiasis, i-trichomoniasis kunye nosulelo lwe-anaerobic