Umgangatho oPhezulu we-L-Glutathione unciphise i-CAS 70-18-8 ye-Skin Care Glutathione

Iinkcukacha zemveliso

MF: C10H17N3O6S
MW: 307.32
CAS: 70-18-8

I-1.I-Glutathione yi-tripeptide ehlanganiswe yi-glutamic acid, i-cysteine ​​kunye ne-glycine ngokusebenzisa iibhondi ze-peptide.Yeyona nto ibalulekileyo ephantsi ye-molecular mercaptan kwiiseli ze-mammalian phantsi koxinzelelo lwe-antioxidant.

I-2.Glutathione (GSH) i-tripeptide compound eyenziwe yi-condensation ye-glutamic acid, i-cysteine ​​kunye ne-glycine ngokusebenzisa iibhondi ze-peptide.Igama layo lekhemikhali ngu-γ- Ifomula yesakhiwo se-l-glutamyl-l-cysteyl-glycine iboniswe kumfanekiso we-1chemicalbook.Ngokwefomula yesakhiwo kumfanekiso, i-GSH yahlukile kwezinye iipeptides kunye neeprotheni.Kukho i-peptide bond ekhethekileyo kwi-molecule yayo, eyenziwe nge-glutamic acid γ- Carboxyl (- COOH) kunye ne-cysteine ​​α- Peptide bond eyenziwe yi-condensation ye-amino - (- NH2).

3.I-molecular weight of glutathione yi-307.33, i-melting point yi-189 ~ 193 ℃ (i-decomposition), i-crystal ayinambala, i-transparent, i-slender column, kunye ne-isoelectric point yi-5.93.Inyibilika emanzini, i-alcohol encibilikayo, i-ammonia engamanzi kunye ne-methyl formamide, kodwa ayinyibiliki etywaleni, ether kunye ne-acetone.Kuphela i-GSH inomsebenzi we-physiological ku-organism, kwaye i-GSSG inokudlala umsebenzi wayo obalulekileyo we-physiological emva kokunciphisa.I-GSH ayilula ukuyigcina phantsi komsebenzi wamanzi aphezulu, kwaye inokugcinwa ngokuzinzileyo ixesha elide kuphela xa umsebenzi wamanzi ulawulwa ngaphantsi kwe-0.3.Izifundo zibonise ukuba kwi-vitamin ccchemicalbook isisombululo esinamanzi esine-GSH (ph3.3), ngenxa yokunciphisa okunamandla kwe-vitamin C, i-GSH kwisisombululo ayiyi kuba ne-oxidized kwi-GSSG, kodwa isantya sayo sokubola sikhawuleza;I-GSSG kwi-vitamin C isisombululo samanzi asiyi kuguqulwa sibe yi-GSH, kwaye ukuzinza kwayo kokugcina kuhle kakhulu.Ngaphezu koko, i-GSSG efakwe ngomlomo ingancitshiswa ibe yi-GSH kwindawo ephezulu yamathumbu amancinci, kunye nomphezulu weeseli ze-epithelial zamathumbu amancinci γ- GTP (obolisa i-GSH kwi-glutamic acid kunye ne-Cys Gly) kunye ne-dipeptidase nayo inokudlala i-physiological ebalulekileyo. imisebenzi.

I-4.Glutathione ikhona ngokubanzi kwizilwanyana kunye nezityalo, kwaye umxholo wayo kwimvubelo yokubhaka, intsholongwane yengqolowa kunye nesibindi sesilwanyana siphezulu kakhulu, ukuya kwi-100 ~ 1000mg / 100g;Ikwatyebile kwigazi lomntu nelezilwanyana, njenge-26chemicalbook ~ 34mg/100g egazini lomntu, 58 ~ 73mg/100g egazini lenkukhu, 10 ~ 15mg/100g egazini lehagu kunye ne-14 ~ 22mg/100g egazini lenja.I-GSH ikwafumaneka kwimifuno emininzi, iitapile kunye neenkozo.

Isicelo

I-1.I-glutathione encitshisiweyo yi-peptide encinci ye-molecule, ekhoyo ngobuninzi kwizinto eziphilayo, ngakumbi kwiiseli zesibindi.Inokukhusela i-membrane yeseli yesibindi, ikhuthaze umsebenzi we-enzyme yesibindi, kwaye idibanise kunye neekhemikhali ezinobuthi ezininzi kwi-chemicalbook detoxify.Inefuthe elihle kwingozi yesibindi, i-cirrhosis yesibindi kunye nezinye izifo ezibangelwa yityhefu yeziyobisi, utywala kunye nezinye izizathu.

I-2.Inemisebenzi ye-antioxidation, i-scavenging radicals yamahhala, i-detoxification, i-immunity yokuphucula, ukulibazisa ukuguga, ukulwa nomhlaza, umonakalo we-radiation anti njalo njalo.

I-3.Ii-reagents ze-biochemical kunye ne-antidotes zisetyenziselwa i-poisoning yesinyithi esinzima, i-acrylonitrile, i-fluoride, i-carbon monoxide kunye ne-solvents eziphilayo.

I-4.I-antioxidants ye-Endogenous edlala indima ebalulekileyo ekunciphiseni iintlobo ze-oksijini ezisebenzayo ezenziwe ngexesha le-cell metabolism kunye nokuphefumula ngokukhawuleza.I-Glutathione-S-transferase ibangela ukubunjwa kwe-glutathione sulfide kunye ne-xenobiotics, i-leukotrienes kunye nezinye iimolekyuli ezinamaziko e-electrophilic.I-Glutathione iphinda yenza iibhondi ze-disulfide kunye neentsalela ze-cysteine ​​​​kwiiprotheni.Ngokusebenzisa ezi ndlela, kunokuba nefuthe elingaqhelekanga lokunciphisa ukusebenza kwe-anticancer agents.